Laboratory Analytical Instrument
The quality assessment of your biopharmaceuticals deserves the best. Using capillary electrophoresis (CE) on the PA800 Plus system lets you challenge the status quo and break through analytical boundaries.
Ultra-high quality separation day in and day out with intuitive kit-based applications for capillary capillary electrophoresis sodium dodecyl sulfate (CE-SDS), capillary gel electrophoresis (CGE), capillary isoelectric focusing (cIEF) and capillary zone electrophoresis (CZE) will help you understand your biotherapeutics and vaccines better to advance them with confidence.
The PA 800 Plus system can help you with:
· Monoclonal antibodies (mAbs) and mAb variants
· Charge heterogeneity (cIEF)
· Purity of mAbs and mAb variants (CE-SDS)
· N-linked gylcan analysis
· In vitro transcribed RNA (IVT RNA)
· Purity and integrity of mRNA and other IVT RNA (CGE)
· Purity and size of critical starting material (CGE)
· Viral vectors
· Capsid protein purity and ratios (CE-SDS)
· Virus genome integrity (CGE)
· Empty-full capsid ratio (CGE and CE-SDS)
· Purity of critical starting material (CGE)
· Residual host cell DNA (CGE)
· Gene editing
· Purity of guide RNA (CGE)
· Purity and integrity of Cas9 mRNA (CGE)
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PA 800 Plus system (P/N: A66528)
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Includes separation module with UV, photodiode array and LIF detection and system controller with PA 800 Plus software.
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Electrical requirements
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Voltage: 100 – 240 V; 50/60 Hz
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Voltage range
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1 to 30 kV programmable at 0.1 kV increments
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Current range
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3 to 300 μA programmable at 0.1 μA increments
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Pressure delivery range
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-5 to +100 PSI
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Sample temperature control
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4 – 60°C
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Capillary temperature control
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15 – 60°C
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Sample trays: 2 x 96-well plates
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2 x 48 universal vials 2 x 48 0.2 mL microvials
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Detection capability
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UV/Vis 200, 214, 254, 280 nm standard filter
190 – 600 nm (custom filter option) Diode array: 190 – 600 nm (programmable) 0.5 – 32 Hz scan collection frequency (programmable) Laser induced fluorescence (LIF): 300 – 700 nm excitation range 350 – 750 nm emission range 0 – 1000 RFU |
